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A framework for community-based development of standards - for harmonization of High-throughput Sequencing (HTS) computations and data formats to promote interoperability and bioinformatics verification protocols.  


2017 HTS COMPUTATIONAL STANDARDS FOR REGULATORY SCIENCES WORKSHOP | MARCH 16 & 17, 2017
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Project Description Harmonization of HTS Computations Biocompute Objects
HTS-CSRS is funded by the US Food and Drug Administration (FDA) for the development of HTS standards for validating data and computations while encouraging interoperability. Our goal is to leverage existing HTS analysis and reporting standards to produce a powerful, standardized and community-centric infrastructure for reporting computations related to regulatory analysis of HTS data. Increasing growth and falling costs of HTS technology constitutes a new challenge in the standardization of computations. GW in collaboration with the FDA is organizing this workshop to facilitate discussions about HTS computational workflows relevant to regulatory sciences. The goal of the workshop is to create a set of recommendations for reporting computations to FDA. Biocompute objects are a record that include all of the following: software arguments, associated metadata of executable program/s, software version information, a reference to all inputs, a reference to all outputs, a usability domain, and validation kits. Biocompute objects will allow accurate evaluation of computations while promoting interoperability, transparency and scientific integrity in regulatory sciences.






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